Evidence based is the base for Nutraceutical
Let Science evident speak for itself, supplement knowledge before supplementation

International Nutraceutical Symposium hosted by Taiwanese Nutraceutical Promotion Association on December 14th, 2013, with medical and academic guests from Taiwan, United States, Hong Kong, Macao, Singapore, Malaysia, and Australia. Former Academia Sinica president, current International Council for Science (ICSU) president, Professor Yuan-Tseh Lee also indicate that nutraceutical is very important, however, there weren't a complete plan with current execution, the public is lacking the knowledge, and hoping the scientist in the field will continue the work and benefit the public in Taiwan.

Zhaoping Li, M.D., Ph.D. JAMA, Annals of International Medicine journal for over 60 articles, over intake of calories can increase fat cell production, and cause chronic inflammation, and this is the best environment for cancer cells growth. Inflammation not only is related to cancer, but also cardiovascular, autoimmune disease, type II diabetes, dementia and other diseases. Professor Zhaoping Li and her research team is eager to find the inflammation mechanism caused from fat cells, and future to balance the over inflammation symptoms by natural anti-inflammation nutrients.
The best anti-inflammatory is w-3 fatty acid, with fish oil, flex seed oil, and canola oil contain the most concentration. However, people now a day are lacking w-3 fatty acid in the diet, plus the increase intake of the sugary drink, they are also drinking in the inflammatory.

Research found that "selenium yeast" has significant effect on inhibiting cancer cells. Professor Chen also reminded everyone that although amino acid selenium and sodium selenide can toxified cancer cells, but can kill the normal cell at the same time, he suggests using selenium yeast when supplementing.

Professor Kao from Hong Koung technology college nutraceutical department reviewed many science thesis and found that "selenium yeast" not only benefit the cells research but also proven in the animal study that it not only shrink the tumor size but also able to inhibit the spreading.
With the lack of the knowledge of the general public, there are chances of taking toxic selenium supplementation, thus it is suggest choosing "selenium yeast" that has enough scientific evidence.

Cancer stem cells is the main cause for cancer recurrent and spreading, his inicial research result showed, the key to inhibit breast cancer stem cell growth is not the drug, but the essential nutrient – fish oil, and specifically the natural TG form of fish oil from safe process. Nutritionist from Taiwan Nutraceutical Association also point out some negative cancer causing report from researches around the world. But the fish oil that these researches are using was all Ethyl Easter (EE) form of fish oil that was created from process involving the mixture of chemical solvents, and this definitely would cause an adverse effect.

Professor Wang also notice that cancer cachexia was caused by lung cancer and many other cancer, in lung cancer mice for research, given complex nutrition regimen while taking chemo and radiation therapies, the result show great significant improvement for cancer cachexia symptoms, and greatly improve mice immunity and increase the ability to fight cancer and prolong survival time.

Haematological Oncologist, Dr. Yei found in his research that neck head cancer patients with nutrition intervention had improved nutrition level and increased body weight, number of completion of the treatment has also increased, Dr Yei also suggested including nutritionist in the treatment team to complete the clinical research.

Professor Li from UCLA medical department also suggest that sole nutrients in tumor or other disease treatment intervention was not significant, balanced supplementation will have the synergistic effect with other complete nutrients, as a result, nutraceutical is growing in many clinical settings.

Professor Lin has been partner with veteran hospital to work on supplementing coronary artery heart disease patients with coenzyme Q10. After daily supplementation of coenzyme Q10, patients' oxidation level has decreased, at the same time the antioxidant activity has increased, and the higher the dosage the more effect the result showed, and can even raise the co enzyme Q10 level in these patients back to normal range of concentration.

Associate professor Dr Chang from Chin Yi University Food and Nutritionist Department has extent the research on diabetes project and further found that the kidney disease caused by diabetes can be improved by using nutraceutical supplementation (Antioxidants, Co Enzyme Q10, and Natural TG form of fish oil), it not only stabilized blood sugar but also effectively improve kidney functions. So far this nutraceutical concept has been established in the research template, and will be apply in clinical trial to benefit more patients.

How to Prevent and Fight Against Cancer? Taiwanese Nutraceutical Association Funder, Simon Hsia, PhD, and Chao Ping Li from UCLA Medical Center suggest that increase intake of colorful fruits and vegetables to increase antioxidantion ability, supplement probiotic and prebiotic is also important; fish oil, canola oil, flaxseed oil can also balance daily intake ratio of w-3 and w-6 fatty acid, regular exercise is also one of the essentials.

	Chairman, ICSU, International Council of Scientific Unions
	Professor Yuan-Tseh Lee
	One of the most famous scientists in Taiwan, and Nobel Prize winner in 1986, and now the chairman of ICSU.

	Taiwanese Nutraceutical Association Founder
	Simon Hsia, PhD
	Dr. Simon Hsia not only has PhD in radiology chemistry from university of California – Irvine, but also the founder of Do Well Laboratories, with many years of research in nutraceutical and promoting partnership between different industries and academic institute.

	UCLA School of Medicine and Department of Clinical Nutrition Professor
	Zhaoping Li, M.D. Ph.D
	Dr Li has been in medical research filed for more than 20 years, and been outstanding in clinical nutrition research; and she has published at least 60 peer reviewed research articles in prestigious journals such as JAMA and the Annals of Internal Medicine.

	Taiwanese Nutrition Association, Chairman
	Gou Shin Wang, PhD
	Dr Wang graduated from Prude University with Master in Nutrition, focusing on mineral nutrition and clinical nutrition, was the lead editor from Taiwan Nutrition Association Magazine and published many outstanding thesis and articles.

	Taiwanese Nutraceutical Association Chairman
	Bo Chung Chen, PhD
	Dr. Chen had served in Choung Shin University and started the Nutraceutical Master program in Hong Koung University, and has been devoted in basic science research; he also published more than ten thesis in different journals international.

	Chia Yi Chang Gung Hospital
	Guan Der Li, MD
	Dr Li from hematology department also professionalized in molecular, cancer clinical testing, cancer molecular gene research and stem cell research, at the same time Dr Li is also an outstanding doctor in Chia Yi Chang Gung Hospital teaching University.

	Wang Fong Medical Center Teaching and Research Department
	Chi Ming Lai, MD
	Dr Lai is outstanding in hematology and cancer research, with 15 years of clinical experience; he was also involving in research in united state national institute of health and Taiwan national institute of health research center for eight years.

	Taiwan Ocean University Food Science Department Professor Researcher
	Hang Wang, PhD
	Dr Wang graduated from Taiwan Ocean University Food Science Department; currently teach at TransWorld University and as researcher in Natioanl Science Association.

	Hong Goung Technology University Nutraceutical Department Professor
	Chi Hong Kao PhD
	Dr Kao currently serves at Hong Goung Technology University Nutraceutical Department, and a board member of Taiwanese Nutraceutical Association.

	Keelung Chungen Hospital Cancer Center Chairman
	Chen Shi Wang, MD
	Dr Wang specialized in cancer treatment, and spends extra care on every patients regardless their status. Besides working in hospital, he is also the chairman in Cancer Hope Association and was the director for Taiwan Cancer Palliative Care Medical Association.

	Keelung Chungen Hospital Internal Medicine and Hematology Director
	Koung Yong Ye, MD
	Dr Ye was an outstanding student since school year; he graduated from University of Rochester, and got his PhD in immunology. After returning to Taiwan, he focus on immune system and cancer treatment, and a well known cancer treatment doctor in Taiwan.

	Chung Shan Medical University Health Management Department Chairman
	Yi Chai Whang, PhD
	Dr Whang not only participated in Royal Cooking publishing, but were also awarded with outstanding performance from National Science Association for college and university.

	Chung Shan Medical University Nutrition Department Associate Professor
	Ping Ting Lin, PhD
	Dr Lin specializes in heart disease research, studying many different types of nutrients such as Co Enzyme Q10 effectiveness to heart disease, her outstanding performance had been recognized in national medical journal and also been used in academic text books.

	Providence University Food Science and Human Nutrition Department Chair
	Kon Jue Chang PhD
	Dr. Chang graduated from Georgia University Food Science and Human Nutrition Department, focused in diabetic research, including blood sugar, blood lipid, kidney disease, blood coagulation, atherosclerosis, inflammation, and antioxidation ability, and had published many research results in nutrition and other major symposium, and also were rewarded with many teaching research award, at the same time an lead editor and chair for Taiwanese Nutrition Association, and has great contribution to the nutrition and academic field.

Nutraceutical is a fairly new knowledge, since 1989 when Dr. Stephen L. DeFelice proposed the idea, recently Nutraceutical research has accumulate increasingly in United State, it shows that this in important in maintaining health in medical treatment, and nutrition intervention is becoming one of the medical revolution plan.
However, nutraceutical is still behind in Taiwan medical field. How to catch up? Mother of the tumor treatment, professor Pong Wang Chia Kan, chair from National Research Center, invited medical, pharmaceutical, nutrition, and academic scientists to participate in the meeting on December 14th, 2013, discussed the medical revolution in Taiwan.
The participants of the meeting included doctors, professors, tumor and other specialty scientists, medical doctors from Hong Kong and Australia. Founder of Taiwanese Nutraceutical Promotion Association, Simon Hsia also invited Dr. Zhaoping Li from UCLA School of Medicine and Department of Clinical Nutrition to participate and bring contribution to the meeting.

Academia Sinica Scientist Lu Hai Wang used the research of "selected Vegetables" (SV) in united state as example to promote nutraceutical in Taiwan.

National Taiwan Medical University Pharmacology Department Professor Show In Shu also suggested the difference between combination and single regimen in medicine regimen.

Shin Kong Hospital Oncology Department Chair Koung Hau Li was hoping that the government regulation can be improved for the the difficulties they faced when the doctors promote nutraceutical.

UCLA School of Medicine and Department of Clinical Nutrition Dr. Zhaoping Li provided the concept of the organization division from research labs, to animal studies, to human clinical research from Human Research Center in UCLA to the meeting, and this information is what was lacking in Taiwan research institutes.

Chen Chin Hospital E.N.T Department Chair Dr Liu shared the journey of entering nutraceutical field, with the support from the president of the hospital, Dr Chang; the nutraceutical outpatient service has become the most popular one.

Linkou Chang Gung Memorial Hospital Vice president, Chin Long Haung: "As a clinical medical doctor, I am optimistic about nutraceutical promotion"

ChiaYi Chang Gung Memorial Hospital Vice president, Guan Der Li: "Medical doctors are behind with the knowledge of nutraceutical, compared with the United States, the medical school in Taiwan is lacking the education in this field, and using United States' teaching experience to increase medical doctors' knowledge in nutrition is necessary."

Keelong Chang Gung Memorial Hospital Cancer Center Chairman, Dr. Chen Shui Wang: "there needs to be a stratigie on promoting the importance of nutraceutical development to the government and health department, nutraceutical is directly related to the patients' health, it is necessary to set the law and the regulations."

Taipei Veteran Hospital Yu Ming Liu, MD,: "General over the counter supplement and health food is for supplementing nutrients, but academic curriculum should be adding one more course on nutrition intervention on treating disease, and let people understand the difference between nutrition supplementation is different than general health maintenance."

On Oct 14 2012, Taiwanese Nutraceutical Association (TNA) hosted the Nutraceutical for Complementary and Integrated Medicine Forum to invite several prestigious scientists and clinical doctors involved in nutraceutical research, to present their recent findings. The forum included 20 research findings, including animal study, in vivo study, and human clinical study, and among those, the inhibition of tumor growth is one of the outstanding founding. This forum reached about 500 attendees, TNA hoped to use this opportunity to spread the importance of nutraceutical in disease prevention and aiding treatments.

A 52 year old lady was diagnosed with stage 4 liver cancer, and was told to follow "starve diet" to starve the cancer cell, but died from liver failure. Dr Yeh Coung Yong from Keelong Chang Gung Memorial Hospital stated that cancer patients will experience weight loss or even death due to cancer cell over growth and taking up most of the nutrients, plus the body cannot absorb nutrients well during treatment, patients need more complete nutrients. Dr Yeh let 68 head neck cancer patients took complete nutrients during treatment and found that patients' BMI, prealbumin, and albumin were all improved.

Besides, Professor Wu Chang Cher and Wang Hang from National Ocean University Food Science Department also found that mice with tumor when supplementing complete nutrients that contain natural TG form fish oil and yeast form selenium can increase mice's immune system and survival rate. TNA chairman Chen Bo Chong state that, selenium promotes cell apoptosis and prevent cancer, but different selenium has different outcome, yeast form selenium is nontoxic, thus it can also protect normal healthy cells.

Professor Chang Chong Chu from Providence University published 2 research articles on controlling and preventing diabetes and slowing the complication, result showed that bitter melon extract and antioxidants can reduce inflammation in blood vessels and slow the thrombosis complication. Dr. Chen Shi Jua from Chen Chin Hospital gave this regimen to type 2 diabetes patients for research, and found that when given proper dosage, it can help controlling blood sugar, and reduce lipid oxidation, reduce endothelial damage.

Professor Kao Chi Hong from Hong Koung Technology University found that complete nutrients combination can increase dopamine and serotonin concentration in depression patients, and liver kidney functions were not affected. Dr Kao think state that nutrients supplementation is very important to add in the treatment.

Chen Chin Hospital E.N.T Department Chair Dr Liu Bo Zen's research "Asthma patients with nutrition supplementation intervention" result showed that it can increase antioxidation ability, decrease inflammatory allergy reaction, improve cell balance and lung function, and control asthma efficiency. This is the first nutraceutical research published in Taiwan.

Nutraceutical has been as one of the main stream in medical care, many countries also cover insurance for nutrition consultation and supplementation. TNA founder Simon Hsia, PhD, suggested that promoting nutraceutical need the team work between medical doctors, pharmacist, dietitian, nurse, and product scientist to create the best benefit for public health.